This community was named for Peter Andrews, who settled in the Wildhorse Valley about 1880. The post office was established October 6, 1890, on Andrews's property, later the Kueny Ranch, with Andrews first postmaster. In 1900, the office was moved a short distance north to the locality. called Wildhorse or Wild Horse, on property owned by George A. Smyth, Jr., and Smyth became postmaster. Some local citizens referred to Wildhorse disparagingly as "Wild Hog," so Smyth changed the name to Andrews in compliment to his friend. Like many other communities in southeast Oregon, the population and facilities at Andrews declined until in 1996 there was one house and one resident, Johnie "Cactus" Smyth, a grandson of George A. Smyth, Jr. The house burned to the ground in July 1996, and now Andrews is truly no more. The Oregonian, December 3, 1996, pg. D6, has a short story with a picture of Smyth.